Do you think is better to sprite small if the sprite is going to end being at small size?

In 3d, when you work on textures if its going to be of a small size (<256) you go faster if you work at a small size because if you resize its a waste of time fixing things.

So, as a newbie at pixel I ask...

Thanks! I Actually sprite characters at 250px x 250px or so, that way I have enough space for the design I want, then I reduce and fix.