With the exception of a few spots where I break the 2x2 block rule, it'd work on most any cart. Only a few carts shipped with a mapper that could switch palettes within a 2x2 tile block, but I don't do that too often in this one!
Really nice tilework here, great attention to lighting everywhere but the top right, one of the black pipes has a highlight there but nowhere else? That just struck me as odd :P
the lighting totally makes this piece. only criticism is that the lights at the bottom of the screen (the small ones) seem out of place. I would have liked it to remain dark to emphasize the light parts.
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I like this!