This is a birthday invitation I did for a friend, who's son is about to turn 1. All of it is hand-pixeled, except for the opacity effect of the 1up, but I felt that wasn't as bad as a brush, and I also felt that it was relevant to the video game theme since it mimics what the 1up would do. 

If I counted right, it's 11 colors, plus the additional colors added by the opacity.