The hand is cool. The nose looks amputated to me. I wonder what you could add to make this seem more like a woman. Maybe if the glasses were Cat's-eye and he had a bonnet instead of that hat. Or give her earrings and a necklace. Lipstick.. tampon... something girly.
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Weekly Challenge: He-She
You could use some more AA to make the lines looks smoother -> more cartoony.